We are a research group at the Guangzhou Laboratory. We are a research group at the Guangzhou Laboratory. If you are interested in working with us, please see more information on (Vacancies).
RNA centre (Miao lab) is a computational biology laboratory, which focuses on the research of RNA structure, function ( RNA structural informatics ) and single-cell omics sequencing. We develop new computaitonal approaches (algorithms, databases, integrated computational workflows) to understand the RNA function at regulation level and structure level.
RNA structural informatics:
Our lab seeks an agile and predictive understanding of how RNAs code for information processing and replication in living systems. We are creating new computational and chemical tools to enable the precise modeling and design of these RNAs.
We have a longstanding interest in understanding global principles of gene regulation and protein-RNA interactions. We use state-of-the-art genomics approaches, including multi-modal single cell genomics and spatial genomics in combination with machine learning methods to advance our knowledge of cells and tissues.
We are looking for passionate Associate Investigators, Postdocs, Assistant Investigators and Research Assistants to join the team (more info) !
We are grateful for funding from Guangzhou Laboratory (Gzlab), MOST and NSFC .
6. May 2023
Ying Ao will join the lab as a graduate student.
14. Apr 2023
Lahong Xu is joining the lab as a Postdoc.
30. Mar 2023
Recently, Prof. Zhichao Miao and Prof.Jules A Hoffmann collaborated on an article entitled Single Cell Analysis of the Fate of Injected Oncogenic RasV12 Cells in Adult Wild Type Drosophila in the Journal of innate immunity, They have injected dish-cultured oncogenic RasV12 cells into adult male flies and analyzed by single cell transcriptomics their destiny within the host after 11 days.They identified in the preinjection samples and in the 11-day postinjection samples in all 16 clusters of cells, of which 5 disappeared during the experiment in the host,and they hypothesize that this results from a bitter dialogue between the injected cells and the host, while the experiments presented here should contribute to deciphering this dialogue
1. Mar 2023
Yan Liu is joining the lab as a Research Assistant.
24. Feb 2023
Recently, Prof. Zhichao Miao and Prof.Zhaoming Su collaborated on an article entitled Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence in the Cell Research, an intercellular communication network based on cell density, quorum sensing (QS), regulates numerous gene expressions including those related to both acute and chronic virulence of P. aeruginosa. The global regulatory protein of the repressor of secondary metabolites (Rsm) system in bacteria, RsmA, is found to predominantly regulate these virulence entities in P. aeruginosa by modulating related gene expressions at transcriptional and posttranscriptional levels.
24. Feb 2023
Recently, Prof. Zhichao Miao and Prof.Xinwen Chen collaborated on an articleSterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association in the Journal of Medical virology, they found that MST3 interacts with the viral proteins NS2A and prM; and MST3 enhances the interaction of NS2A–NS4A.Thus, MST3-NS2A complex plays a major role in recruiting prM–E heterodimers and NS4A and mediates the virion assembly. Additionally, we found that MST3 was biotinylated and combined with other proteins (e.g., ATG5, Sec24A, and SNX4) that are associated with the cellular membrane required for TBEV infection. Overall, their study revealed a novel function for MST3 in TBEV infection and identified as a novel host factor supporting TBEV assembly
13. Feb 2023
Jiuhong Jiang is joining the lab as a Research Assistant.
10. Feb 2023
Shuo Feng is joining the lab as an Intern.
9. Feb 2023
Bowen Xiao is joining the lab as a Research Assistant.