RNA centre (Miao lab) is a computational biology laboratory, which focuses on the research of RNA structure, function ( RNA structural informatics ) and single-cell omics sequencing. We develop new computaitonal approaches (algorithms, databases, integrated computational workflows) to understand the RNA function at regulation level and structure level.
RNA structural informatics:
Our lab seeks an agile and predictive understanding of how RNAs code for information processing and replication in living systems. We are creating new computational and chemical tools to enable the precise modeling and design of these RNAs.
We have a longstanding interest in understanding global principles of gene regulation and protein-RNA interactions. We use state-of-the-art genomics approaches, including multi-modal single cell genomics and spatial genomics in combination with machine learning methods to advance our knowledge of cells and tissues.
We are looking for passionate Associate Investigators, Postdocs, Assistant Investigators and Research Assistants to join the team (more info) !
13. Dec 2022
Recently, Prof.Zhichao Miao, Prof.Amjad Khan, and Prof.Muhammad Khisroon collaborated on an article entitled Exome sequencing identifies homozygous variants in MBOAT7 associated with neurodevelopmental disorder in the Clinical Genetics. They dentified three novel homozygous missense variants (NM_024298.5: c.588G > T; p.Trp196Cys, c.736 T > C; p.Tyr246His and c.524A > C; p. Asp175Ala) and one rare homozygous in-frame deletion variant (c.758_778del;p.Glu253_Ala259del) in membrane-bound O-acyltransferase family member 7 (MBOAT7) gene previously associated with autosomal recessive neurodevelopmental disorder.
1. Nov 2023
Bichun Wu is joining the lab as a Intern.
1. Nov 2023
Xiaofeng Chen is joining the lab as a Research Assistant.
26. Oct 2022
Recently, Prof.Zhichao Miao and Prof.Qiong Zhang co-published an article entitled Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy in the RNA Biology, They explored the pivotal roles of viral circRNAs and associated RNA in various biological processes, and highlighted the applications of circular RNA in biomarker studies as well as circRNA-based therapeutics.
24. Oct 2022
Recently, Prof.Zhichao Miao and Prof.Eric Westhof co-published an article entitled Assessment of three-dimensional RNA structure prediction in CASP15 in the Proteins. They reported assessments of RNA structure predictions in CASP15, the first CASP exercise that involved RNA structure modeling.
19. Oct 2022
Recently, Prof.Zhichao Miao and Prof.Lin Huang co-published an article entitled Ribocentre-switch: a database of riboswitches in the Nucleic Acids Research, Ribocentre-switch may facilitate the understanding of RNA structural conformational changes in response to ligand signaling.The database is publicly available at https://riboswitch.ribocentre.org.
14. Oct 2022
Recently, Prof.Zhichao Miao, Prof.Yuyao Song, and Prof.Irene Papatheodorou collaborated on an article entitled Benchmarking strategies for cross-species integration of single-cell RNA sequencing data in the Nature Communication. They benchmarked 28 combinations of gene homology mapping methods and data integration algorithms in a variety of biological settings and develop a new biology conservation metric to address the maintenance of cell type distinguishability.
13. Oct 2022
Recently, Prof.Zhichao Miao, Prof.Jie Zha, and Prof.Yong Yu collaborated on an article entitled Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung in the BMC Biology. Their findings showed that activated ILC2s are a heterogenous population encompassing distinct subsets that have different propensities, and therefore provide an opportunity to explore PD-1’s role in modulating the activity of ILC2s for disease prevention and therapy.
15. Sep 2023
Hao Sun is joining the lab as a Research Assistant.