We are a research group at the Guangzhou National Laboratory. We are a research group at the Guangzhou Laboratory. If you are interested in working with us, please see more information on (Vacancies).
RNA centre (Miao lab) is a computational biology laboratory, which focuses on the research of RNA structure, function ( RNA structural informatics ) and single-cell omics sequencing. We develop new computaitonal approaches (algorithms, databases, integrated computational workflows) to understand the RNA function at regulation level and structure level.
RNA structural informatics:
Our lab seeks an agile and predictive understanding of how RNAs code for information processing and replication in living systems. We are creating new computational and chemical tools to enable the precise modeling and design of these RNAs.
single-cell omics:
We have a longstanding interest in understanding global principles of gene regulation and protein-RNA interactions. We use state-of-the-art genomics approaches, including multi-modal single cell genomics and spatial genomics in combination with machine learning methods to advance our knowledge of cells and tissues.
We are looking for passionate Associate Investigators, Postdocs, Assistant Investigators and Research Assistants to join the team (more info) !
We are grateful for funding from Guangzhou Laboratory (Gzlab), MOST and NSFC .
1. Jul 2024
Recently, Prof.Zhichao Miao and Prof.Hongjie Yao collaborated on an article entitled CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment in the Nature Communications. This study elucidates the influence of the CTCFR567W mutation on human neurodevelopmental disorders, paving the way for potential therapeutic interventions.
25. May 2024
We published a paper in Neurogenetics Clinical genomics expands the link between erroneous cell division, primary microcephaly and intellectual disabilityThe research suggest that bi-allelic variants in CENPJ, STIL, CDK5RAP2, RBBP8, and CEP135 affect cell cycle progression and cause syndromic or non-syndromic microcephaly and expand the knowledge on genotype–phenotype correlations in variant-associated microcephaly.
21. Apr 2024
Our deconvolution paper at Bioinformatics Advances CATD: a reproducible pipeline for selecting cell-type deconvolution methods across tissues is now available on line.
8. Apr 2024
Linyan Hu is joining the lab as a Research Assistant.
27. Feb 2024
Jiaxin Zhao is joining the lab as a Graduate student.
13. Dec 2023
Recently, Prof.Zhichao Miao, Prof.Amjad Khan, and Prof.Muhammad Khisroon collaborated on an article entitled Exome sequencing identifies homozygous variants in MBOAT7 associated with neurodevelopmental disorder in the Clinical Genetics. They dentified three novel homozygous missense variants (NM_024298.5: c.588G > T; p.Trp196Cys, c.736 T > C; p.Tyr246His and c.524A > C; p. Asp175Ala) and one rare homozygous in-frame deletion variant (c.758_778del;p.Glu253_Ala259del) in membrane-bound O-acyltransferase family member 7 (MBOAT7) gene previously associated with autosomal recessive neurodevelopmental disorder.
1. Nov 2023
Bichun Wu is joining the lab as a Graduate student.
1. Nov 2023
Xiaofeng Chen is joining the lab as a Research Assistant.
26. Oct 2023
Recently, Prof.Zhichao Miao and Prof.Qiong Zhang co-published an article entitled Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy in the RNA Biology, They explored the pivotal roles of viral circRNAs and associated RNA in various biological processes, and highlighted the applications of circular RNA in biomarker studies as well as circRNA-based therapeutics.
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